Etoposide Phosphate is a derivative of Etoposide (VP-16) (sc-3512). Etoposide is a topoisomerase II inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties. Inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Cell-cycle dependent and cell-cycle specific to late S and G2 phases. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells. Etoposide Phosphate is an activator of p53.
See how others have used Etoposide Phosphate. Click on the entry to view the PubMed entry .
PMID: # 27926506 Su, L. et al. 2017. Oncotarget. 8: 2617-2627.
PMID: # 26416623 Lehouritis, P. et al. 2015. Sci Rep. 5: 14554.
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