EtodolacA Cox-2 inhibitor with anti-inflammatory activity

Etodolac (CAS 41340-25-4)

Etodolac | CAS 41340-25-4 is rated 5.0 out of 5 by 1.
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Synonym: Etodolic acid; Etogesic; Lodine; Tedolan; Ultradol
Application: A Cox-2 inhibitor with anti-inflammatory activity
CAS Number: 41340-25-4
Purity: ≥98%
Molecular Weight: 287.35
Molecular Formula: C17H21NO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Etodolac is a Cox-2 inhibitor with anti-inflammatory and analgesic activity. Etodolac is shown to inhibit growth and PCNA expression and induce cell cycle arrest in human hepatocellular carcinoma cell lines, in addition to suppressing the occurrence of aberrant crypt foci and tumors in colitis-induced tumorigenesis in rats. Etodolac is an inhibitor of Cox-1.


References

Cheng J, Imanishi H, Liu W et al. Cancer Sci. 95:666-73 (2004). Takeda J, Kitajima K, Fujii S et al. Oncol Rep. 11:981-5 (2004). Lynch S, Brogden RN. Drugs. 31:288-300 (1986).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at 4° C
Melting Point :
145-148° C
Boiling Point :
~507.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Cox-2: IC50 = 561 nM (human); Cox-1: IC50 = 2.65 µM (human); OAT1: IC50 = 50 µM (human)
Ki Data :
Solute carrier family 22 member 6: Ki>100 µM (rat)
pK Values :
pKa: 4.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ0360000
PubChem CID :
3308
Merck Index :
14: 3874
MDL Number :
MFCD00133313
SMILES :
CCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(=O)O

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Certificate of Analysis

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What is the solubility of this product?

Asked by: hawkeye11
This product is soluble in DMSO (100 mM), and ethanol (100 mM)
Answered by: Tech Service 4
Date published: 2016-12-16
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Rated 5 out of 5 by from Ishiguro et al Ishiguro et al. (PubMed ID 25797973) used the selective cyclooxygenase-2 inhibitor with anti-inflammatory activity, etodolac, to treat post-operative pain. -SCBT Publication Review
Date published: 2015-04-14
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