ETICAS: 13488-22-7
MF: C20H28O2
MW: 300.44
A leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor.

ETI (CAS 13488-22-7)

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Application: A leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor
CAS Number: 13488-22-7
Purity: ≥98%
Molecular Weight: 300.44
Molecular Formula: C20H28O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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ETI, 5,8,11-eicosatriynoic acid, demonstrates the ability to inhibit 5-LO (5-lipoxygenase) activity and halt biosynthesis of leukotriene C4 by mastocytoma cells. Studies suggest that ETI also reduces oxidative metabolism of arachidonic acid (sc-200770). ETI also displays anti-proliferative properties which result from 5-LO selective inhibition and cause a decrease in platelet-induced growth of fibroblast cells. ETI is an inhibitor of 12-LO, 15-LO and GST.


References

1. Orning, L. and Hammarström, S. 1980. J. Biol. Chem. 255: 8023-8026. PMID: 6106018
2. Salari, H., et al. 1984. Prostaglandins Leukot Med. 13: 53-60. PMID: 6424136
3. Berg, C., et al. 2006. Thromb. Haemost. 96: 652-659. PMID: 17080223

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), DMF, water (1 mg/ml), and Tris-HCL,PH8.5 (0.15 M).
Storage :
Store at -20° C
Melting Point :
68-69° C
Boiling Point :
473.77° C at 760 mmHg
Density :
0.99 g/cm3
Refractive Index :
n20D 1.51
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1781
MDL Number :
MFCD00077343
SMILES :
CCCCCCCCC#CCC#CCC#CCCCC(O)=O

Download SDS (MSDS)

Certificate of Analysis

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