Ethynyl Estradiol CAS: 57-63-6
MF: C20H24O2
MW: 296.4
A synthetic estradiol analog.

Ethynyl Estradiol (CAS 57-63-6)

Ethynyl Estradiol | CAS 57-63-6 is rated 5.0 out of 5 by 1.
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Alternate Names: 17α-Ethynylestradiol; 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol; 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol
Application: Ethynyl Estradiol is a synthetic estradiol analog
CAS Number: 57-63-6
Molecular Weight: 296.4
Molecular Formula: C20H24O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestin. Efficacy of administration is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed from gastrointestinal tract.


References

1 Gruber, C.J., Tschugguel, W., Schneeberger, C., et al. Production and actions of estrogens. N Engl J Med 346(5) 340-352 (2002). 2 Coelingh Bennink, H.J.T. Are all estrogens the same?. Maturitas 47 269-275 (2003).

Physical State :
Solid
Solubility :
Soluble in ethanol (59 mg/ml at 25° C), DMF (~20 mg/ml), DMSO (59 mg/ml at 25° C), water (0.01 mg/ml at 27° C), and methanol.
Storage :
Store at -20° C
Melting Point :
182-183° C
Boiling Point :
~457.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -30.7°, c = 1.02 in pyridine; α24/D 3.5°, c = 2 in dioxane; α24/D -29.5°, c = 2 in pyridine
IC50 :
ERα: IC50 = 0.45 nM (human); ERβ: IC50 = 8.1 nM (human); ST: IC50 = 54 nM (human); DATSlc6a3: IC50 = 559 nM (human); AOX1: IC50 = 570 nM (human)
Ki Data :
ERRα: Ki= 0.13 nM (human); ST: Ki= 29 nM (human); PR: Ki= 139 nM (bovine); DATSlc6a3: Ki= 444 nM (human); GR: Ki= 777 nM (human)
pK Values :
pKa: 10.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RC8925000
PubChem CID :
MDL Number :
MFCD00003690
EC Number :
200-342-2
Beilstein Registry :
2419975

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Certificate of Analysis

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Ethynyl Estradiol (CAS 57-63-6)  Product Citations

See how others have used Ethynyl Estradiol (CAS 57-63-6). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26253722  Kataria, H. et al. 2015. Mol. Neurobiol.

PMID: # 28108920  Environ Sci Pollut Res Int. 24: 7392-7402.

Citations 1 to 2 of 2 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Ethynyl Estradiol, sc-205318, is in white or creamy white crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-07-03
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Rated 5 out of 5 by from Ethynyl Estradiol was reported as a synthetic Ethynyl Estradiol was reported as a synthetic analog of estradiol that can be absorbed in the gastrointestial tract. -SCBT Publication Review
Date published: 2015-04-15
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