Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestin. Efficacy of administration is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed from gastrointestinal tract.
1 Gruber, C.J., Tschugguel, W., Schneeberger, C., et al. Production and actions of estrogens. N Engl J Med 346(5) 340-352 (2002). 2 Coelingh Bennink, H.J.T. Are all estrogens the same?. Maturitas 47 269-275 (2003).
Soluble in ethanol (59 mg/ml at 25° C), DMF (~20 mg/ml), DMSO (59 mg/ml at 25° C), water (0.01 mg/ml at 27° C), and methanol.
Store at -20° C
~457.2° C at 760 mmHg (Predicted)
~1.2 g/cm3 (Predicted)
n20D 1.62 (Predicted)
α20/D -30.7°, c = 1.02 in pyridine; α24/D 3.5°, c = 2 in dioxane; α24/D -29.5°, c = 2 in pyridine
Rated 5 out of
Ethynyl Estradiol was reported as a syntheticEthynyl Estradiol was reported as a synthetic analog of estradiol that can be absorbed in the gastrointestial tract. -SCBT Publication Review
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