Ethyl-L-NIO, hydrochloride is the saturated analog of vinyl-L-NIO (sc-222412) and acts as a NOS1 selective inhibitor. Although ethyl-L-NIO inhibits NOS1 (nNOS), this action is inhibited in the presence of NADPH and O2.
1. Babu, B R., et al., 1998. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. The Journal of biological chemistry. 273(15): 8882-9. PMID: 9535869
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