Ethyl 3,4-dihydroxybenzylidenecyanoacetateCAS: 132464-92-7
MF: C12H11NO4
MW: 233.2
A 12-LO and 15-LO inhibitor.

Ethyl 3,4-dihydroxybenzylidenecyanoacetate (CAS 132464-92-7)

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Synonym: 2-(1-thienyl) ethyl 3,4-dihydroxybenzylidenecyanoacetate
Application: A 12-LO and 15-LO inhibitor
CAS Number: 132464-92-7
Purity: ≥96%
Molecular Weight: 233.2
Molecular Formula: C12H11NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ethyl 3,4-dihydroxybenzylidenecyanoacetate is an inhibitor of 12-LO (12-lipoxygenase) and 15-LO (15-lipoxygenase). 12-LO is an enzyme involved in the lipoxygenase pathway and plays a major role in promoting prostate cancer progression and metastasis. 15-LO enzyme has been associated with antherosclerosis and cancer.


References

1. Cho, H., et al. 1991. J. Med. Chem. 34: 1503-1505. PMID: 2016727
2. Krishnamoorthy, S., et al. 2010. Exp. Cell Res. 316: 1706-1715. PMID: 20303950
3. Toledo, L., et al. 2010. J Phys Chem B. 114: 7037-7046. PMID: 20429616

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at 4° C
Boiling Point :
437.92° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Arachidonate 15-lipoxygenase, type II: IC50 = 330 nM (rat); Arachidonate 12-lipoxygenase: IC50 = 33 nM (rat); Arachidonate 5-lipoxygenase: IC50 = >10 µM (rat)
pK Values :
pKa: 8.79 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD00209849

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Certificate of Analysis

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Ethyl 3,4-dihydroxybenzylidenecyanoacetate  Product Citations

See how others have used Ethyl 3,4-dihydroxybenzylidenecyanoacetate. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27709605  Rodríguez, M.|Márquez, S.|de la Rosa, JV.|Alonso, S.|Castrillo, A.|Sánchez Crespo, M.|Fernández, N.| et al. 2017. Immunology. 150: 184-198.

PMID: # 26673542  Rodríguez, M. et al. 2016. Biochem. Pharmacol. 102: 78-96.

Citations 1 to 2 of 2 total
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