Estropipate CAS: 7280-37-7
MF: C18H22O5S.C4H10N2
MW: 436.56
An ER agonist that inhibits OATP1B1.

Estropipate (CAS 7280-37-7)

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Alternate Names: Piperazine estrone sulfate
Application: Estropipate is an ER agonist that inhibits OATP1B1
CAS Number: 7280-37-7
Molecular Weight: 436.56
Molecular Formula: C18H22O5S.C4H10N2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Estropipate is an estrogen receptor (ER) agonist. Estropipate can also inhibit OATP-C (organic anion transporting polypeptide 1B1, OATP1B1) (IC50 = 70 nM).


References

Williams et al (2004) Estrogen regulation of the cytochrome P450 3A subfamily in humans. J.Pharmacol.Exp.Ther. 311 728. Obaidat et al (2009) A cell-based high-throughput assay to identify inhibitors of organic anion transporting polypeptides 1B1 and 1B3. FASEB J. 23 748.2

Physical State :
Solid
Solubility :
Soluble in water (5 mM), DMSO (100 mM), 1.1eq. NaOH (100 mM), alkali hydroxides, and propylene glycol.
Storage :
Store at room temperature
Melting Point :
190° C
Boiling Point :
638.2° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.60 (Predicted)
Optical Activity :
α20/D +92°, c = 1 in 0.4%NaOH; α20/D 110°±10°, c = 1 in DMSO
IC50 :
OATP-C: IC50 = 70 nM; ES: IC50 = 7.6 µM (human); MRP4: IC50 = 45 µM (human)
Ki Data :
OATP-C: Ki= 45.8 nM (human); MRP1: Ki= 0.45 µM (human); Solute carrier organic anion transporter family member 1A1: Ki= 1.3 µM (human); Solute carrier family 22 member 8: Ki= 9.1 µM (rat); Solute carrier organic anion transporter family member 1C1: Ki= 53.1 µM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KG7785000
PubChem CID :
MDL Number :
MFCD00867399
EC Number :
230-696-3
SMILES :
C[[email protected]]12CC[[email protected]]3[[email protected]]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1

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Certificate of Analysis

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Estropipate (CAS 7280-37-7)  Product Citations

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PMID: # 31866203  Dev. Cell.

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