Estropipate is an estrogen receptor (ER) agonist. Estropipate can also inhibit OATP-C (organic anion transporting polypeptide 1B1, OATP1B1) (IC50 = 70 nM).
Williams et al (2004) Estrogen regulation of the cytochrome P450 3A subfamily in humans. J.Pharmacol.Exp.Ther. 311 728. Obaidat et al (2009) A cell-based high-throughput assay to identify inhibitors of organic anion transporting polypeptides 1B1 and 1B3. FASEB J. 23 748.2
Soluble in water (5 mM), DMSO (100 mM), 1.1eq. NaOH (100 mM), alkali hydroxides, and propylene glycol.
Store at room temperature
638.2° C at 760 mmHg (Predicted)
n20D ~1.60 (Predicted)
α20/D +92°, c = 1 in 0.4%NaOH; α20/D 110°±10°, c = 1 in DMSO
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