EstroneAn estradiol metabolite and useful in various tumorigenesis studies

Estrone (CAS 53-16-7)

Estrone | CAS 53-16-7 is rated 5.0 out of 5 by 1.
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Application: An estradiol metabolite and useful in various tumorigenesis studies
CAS Number: 53-16-7
Purity: >95%
Molecular Weight: 270.37
Molecular Formula: C18H22O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Estrone is an estradiol metabolite found to reduce colon cell tumorigenesis, independent of ERα. Also found to inhibit BCRP-mediated drug efflux and overcome drug resistance.


References

1. Imai, Y., et al. 2002. Jpn. J. Cancer Res. 93: 231-235. PMID: 11927002
2. Guo, J.Y., et al. 2004. J. Nutr. 134: 179-182. PMID: 14704314

Physical State :
Solid
Solubility :
Soluble in ethanol (<1 mg/ml at 25° C), water (0.03 g/L), DMSO (54 mg/ml at 25° C), DMF (~20 mg/ml), and chloroform.
Storage :
Store at -20° C
Melting Point :
257.8-260° C
Boiling Point :
~445.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D +167.73°, c = 0.97 in ethanol
IC50 :
ERα: IC50 = 7.65 nM (human); ERβ: IC50 = 31 nM (human); 17β-HSD: IC50 = 109 nM (human); ABCG2: IC50 = 3.00 µM (human); ST: IC50 = 5.30 µM (human)
Ki Data :
ERα: Ki= 2.19 nM (human); 17β-HSD: Ki= 3 nM (human); Progesterone receptor: Ki= 2.10 µM (bovine); ST: Ki= 2.82 µM (human); Androgen Receptor: Ki= 7.75 µM (rat)
pK Values :
pKa: 10.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KG8575000
PubChem CID :
5870
Merck Index :
14: 3708
MDL Number :
MFCD00003620
EC Number :
200-164-5
Beilstein Registry :
1915077
SMILES :
C[C@]12CCC3[C@@H](CCC4=CC(O)=CC=C34)C1CCC2=O

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Certificate of Analysis

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Rated 5 out of 5 by from Imai et al Imai et al. (PubMed ID 11927002) found that estrone enhanced the cytotoxicity of mitoxantrone, SN-38 and topotecan in breast cancer resistance protein (BCRP)-transduced K562 cells. -SCBT Publication Review
Date published: 2015-01-06
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