Estren CAS: 35950-87-9
MF: C18H28O2
MW: 276.41
A steroid ligand.

Estren (CAS 35950-87-9)

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Alternate Names: 4-Estren-3α, 17β-diol
Application: Estren is a steroid ligand
CAS Number: 35950-87-9
Purity: ≥98%
Molecular Weight: 276.41
Molecular Formula: C18H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Estren is a steroid ligand that exhibits lower binding affinity for estrogen receptor and has no classical transcriptional activity. Estren has been shown to attenuate osteoblast apoptosis, stimulate osteoclast apoptosis, and increase bone mass and strength with no affect to reproductive organs in a non-sex-specific mechanism of action. Estren is possibly useful in studies pertaining to hormone replacement therapy for osteoporosis.


References

1. Kousteni, S., et al., 2002. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science (New York, N.Y.). 298(5594): 843-6. PMID: 12399595

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and ethanol.
Storage :
Store at 4° C
Melting Point :
203-207° C
Boiling Point :
431.03° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α20/D +124°±5°, c = 1 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00271605

Download SDS (MSDS)

Certificate of Analysis

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