Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase; 5-LOX) inhibitor. Esculetin is reported to display antiinflammatory and antioxidant properties, as well as induce cell cycle arrest and apoptosis. In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. Additionally, reports demonstrate that Esculetin also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
1. Neichi, T., et al. 1983. Biochim. Biophys. Acta. 753: 130-132. PMID: 6411127 2. Du, L., et al. 2006. J. Biochem. 139: 715-723. PMID: 16672272 3. Kok, S.H., et al. 2009. Oral Oncol. 45: 1067-1072. PMID: 19720557 4. Witaicenis, A., et al. 2010. Chem. Biol. Interact. 186: 211-218. PMID: 20380826 5. Park, C., et al. 2010. Toxicol In Vitro. 24: 486-494. PMID: 19786087
Soluble in DMSO, DMF, 0.1 M NaOH (1 %) yielding a deep yellow solution, diluted alkalies with blue fluorescence, and acetone. Moderately soluble in Glacial acetic acid, and hot ethanol. Slightly soluble in water. Very faint turbidity in hot methanol. Almost insoluble in ether. Insoluble in hot water.
Can I get the synthesis information for sc-200486, lot number 12915 (esculeitn)
Asked by: nnnnnh93
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Park et alPark et al. (PubMed ID 19786087) used Esculetin to induce apoptosis in human U937 leukemia cells by blocking Bcl-2 overexpression and restoring the Bcl-2 inhibitor, HA14-1. -SCBT Publication Review
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