ES-2 Cell Lysate: sc-24674
- 500 µg protein in 200 µl SDS-PAGE Western blotting buffer
- human whole cell lysate; ovary clear cell carcinoma cells
- whole cell lysate provided as Western blotting positive control
- should be stored at -20°C and repeated freezing and thawing should be minimized
- sample vial should be placed at 95° C for up to 5 minutes, once prior to use
QUICK LINKS
SEE ALSO...
ES-2 cell lysate is derived from the ES-2 cell line, a well-established model for clear cell ovarian carcinoma, commonly used in cancer research to explore the pathogenesis and molecular biology of ovarian cancer. This lysate enables scientists to study the cellular and molecular mechanisms associated with aggressive tumor behavior, including rapid growth, metastasis, and resistance to conventional treatments. Researchers use ES-2 lysate to investigate signaling pathways critical for tumor survival and progression, such as the Notch, Wnt, and Hedgehog pathways, which are often aberrantly activated in ovarian cancers. The lysate is particularly valuable for examining the effects of genetic alterations and their impact on cell proliferation, apoptosis, and metastatic potential. Additionally, ES-2 lysate provides a platform for screening potential anti-cancer compounds, allowing for the assessment of their efficacy in inhibiting growth and inducing cell death in cancer cells. By studying these interactions and responses, ES-2 cell lysate contributes significantly to the understanding of cellular responses in ovarian cancer, facilitating advances in basic research aimed at uncovering the underlying mechanisms of disease progression. This research helps to enhance our foundational knowledge of cancer biology, specifically in the context of ovarian cancer.
ES-2 Cell Lysate References:
- Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis. | Bazzaro, M., et al. 2006. Cancer Res. 66: 3754-63. PMID: 16585202
- Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. | Bazzaro, M., et al. 2007. Am J Pathol. 171: 1640-9. PMID: 17872978
- Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. | Coughlin, K., et al. 2014. Clin Cancer Res. 20: 3174-86. PMID: 24727327
- The NF-κB-modulated miR-19a-3p enhances malignancy of human ovarian cancer cells through inhibition of IGFBP-3 expression. | Bai, R., et al. 2019. Mol Carcinog. 58: 2254-2265. PMID: 31513316
- The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer. | Bai, R., et al. 2020. J Cancer. 11: 3433-3445. PMID: 32284739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ES-2 Cell Lysate | sc-24674 | 500 µg/200 µl | $118.00 |