ERp57 Antibody (MaP.ERp57) is a high quality monoclonal ERp57 antibody (also designated ERp60 antibody, P58 antibody, Endoplasmic Reticulum Resident Protein 57 antibody, Protein Disulfide Isomerase-Associated 3 antibody, Glucose Regulated Protein 58kDa antibody, 58 KDa Glucose-Regulated Protein antibody, Protein Disulfide-Isomerase A3 antibody, 58 KDa Microsomal Protein antibody, Disulfide Isomerase ER-60 antibody, ER Protein 57 antibody, ER Protein 60 antibody, PI-PLC antibody, ERp61 antibody, GRP57 antibody, GRP58 antibody, Endoplasmic Reticulum P58 antibody, ERP60 antibody, or ER60 antibody) suitable for the detection of the ERp57 protein of mouse, rat and human origin. ERp57 Antibody (MaP.ERp57) is available as both the non-conjugated anti-ERp57 antibody form, as well as multiple conjugated forms of anti-ERp57 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically-derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell. Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides. MHC class I molecules assemble in the endoplasmic reticulum with chaperones before binding to the transporter associated with antigen processing (TAP). ERp57, also designated GRP57, GRP58, ERp60 and ERp61, is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP. The human ERp57 gene maps to chromosome 15q15 and encodes a 505 amino acid protein. ERp57 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals. ERp57 may act as a protease, a protein disulfide isomerase, a phospholipase or a combination of these.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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