ERK Inhibitor II Negative ControlA negative control for ERK Inhibitor II

ERK Inhibitor II, Negative Control (CAS 1177970-73-8)

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Synonym: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol
Application: A negative control for ERK Inhibitor II
CAS Number: 1177970-73-8
Molecular Weight: 328.3
Molecular Formula: C18H12N6O
* Refer to Certificate of Analysis for lot specific data (including water content).
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ERK Inhibitor II, Negative Control is a cell-permeable pyrazolopyridazinol that serves as a (-) control for ERK Inhibitor II. ERK Inhibitor II, Negative Control has been shown to exhibit little activity towards ERK1 and ERK2 or in blocking TGF-β-induced AP-1 activation in Mv1Lu epithelial cells.


References

Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.83 (Predicted)
IC50 :
ERK1: IC50 = >100 µM; ERK2: IC50 = >100 µM; TGF-β-induced AP-1 activation: IC50 = >10 µM (Mv1Lu epithelial cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760417
SMILES :
C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=NN=C5C(=C4)C(=O)NN5

Download SDS (MSDS)

Certificate of Analysis

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