Epothilone AAn antitubulin agent

Epothilone A (CAS 152044-53-6)

Epothilone A | CAS 152044-53-6 is rated 5.0 out of 5 by 1.
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Synonym: (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9, 9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13, 17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
Application: An antitubulin agent
CAS Number: 152044-53-6
Purity: >95%
Molecular Weight: 493.66
Molecular Formula: C26H39NO6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Epothilone A is a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A and B were isolated from Sorangium cellulosum and was associated with cell cycle arrest at G2/M transition and apoptosis.


References

Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995), Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001), Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)

Appearance :
Powder
Physical State :
Solid
Storage :
Desiccate at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
448799
Merck Index :
14: 03628
SMILES :
C[C@H]1CCC[C@@H]2[C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Rogalska et al Rogalska et al. (PubMed ID 22995584) found that epothilone A showed antiproliferative activity in the SKOV-3 cell line by decreasing mitochondrial membrane potential, thus promoting necrosis and apoptosis. -SCBT Publication Review
Date published: 2015-06-22
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