Eplerenone is an aldosterone antagonist with more specificity for the mineralocorticoid receptor (MCR) than spironolactone (sc-204294), having lower affinity for progesterone, androgen, and glucocorticoid receptors.
De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650. McMahon (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190.
Soluble in DMSO (10 mM), water (very slightly), ethanol (slightly), methanol (sparingly), and chloroform.
Thank you for your question. The solubility for sc-203943 is as follows: DMSO 4mg/mL (9.65 mM) warming, Water <1mg/mL, and Ethanol <1mg/mL. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing email@example.com, or using the Live Chat function on our website.
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OhtaniOhtani, T. et al. (PubMed 17023667) used eplerenone, a selective mineralocorticoid receptor antagonist, on Dahl salt-sensitive rats exhibiting diastolic heart failure (DHF). Introduction of eplerenone led to prevention of overt DHF by blockade of the mineralocorticoid receptor. -SCBT Publication Review
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