Epirubicin Hydrochloride is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin (sc-280681) that exhibits reduced cardiotoxicity. Epirubicin Hydrochloride's antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II).
Luck, H.J., et al. 1996. Semin. Oncol. 23, 33. Sandri, M.I., et al. 1996. Br. J. Cancer 73, 1518. Boddy, A.V., et al. 1995. Eur. J. Cancer 31A, 69. Pouna, P., et al. 1995. Cancer. Chemother. Pharmacol. 35, 257. R: 20/21/22-40; S: 22-36
Soluble in water (116 mg/mL) at 25° C, DMSO (116 mg/mL) at 25° C, ethanol (3 mg/mL) at 25° C, acetone, and methanol.
Store at 4° C
185° C (dec.)
810.3° C at 760 mmHg (Predicted)
n20D ~1.71 (Predicted)
α20/D 274°, c = 0.01 in methanol
the synthesis and function of DNA: IC50 = 62.7 µM ( rat glioblastoma cell lines)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Is epirubicin soluble in absolute ethanol
Asked by: Mdrdsg
Thank you for your question. We recommend solubilizing in 3 mg/mL at 25° C in ethanol.
Answered by: Technical Support
Date published: 2018-12-05
How long (and at what conditions) is this product stable after dissolution in water? In DMSO?
Asked by: two2igm05
Thank you for your question. Once the compound has been reconstituted in DMSO, it can remain stable for up to 6 months if stored at -80ºC. In general, we recommend that stock solutions, once prepared, are aliquoted in tightly sealed vials and stored at -20°C or below to be used within 1 month. Wherever possible, though, solutions should be made up and used on the same day. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing email@example.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as an orange-red crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing firstname.lastname@example.org, or using the Live Chat function on our website.
Rated 5 out of
Trissel LA; et alTrissel LA; et al. (PubMed ID: 15613463) determined that Epirubicin Hydrochloride in combination with doxorubicin hydrochloride stabilizes Palonosetron hydrochloride for 4hours after administrations. -SCBT Publication Review
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