(-)-Epinephrine CAS: 51-43-4
MF: C9H13NO3
MW: 183.20
An adrenoceptor activator.

(-)-Epinephrine (CAS 51-43-4)

(-)-Epinephrine | CAS 51-43-4 is rated 5.0 out of 5 by 1.
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Alternate Names: (-)-Adrenalin; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
Application: (−)-Epinephrine is an adrenoceptor activator
CAS Number: 51-43-4
Purity: ≥98%
Molecular Weight: 183.20
Molecular Formula: C9H13NO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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(-)-Epinephrine is a predominent neurotransmitter. (-)-Epinephrine has been found to be an effective β2-agonist and bronchiodialator. (-)-Epinephrine is an activator of β2-AR.


References

1. Rosol, T.J., et al. 2001. Toxicol Pathol. 29: 41-48. PMID: 11215683
2. King, V.J., et al. 2004. Arch. Pediatr. Adolesc. Med. 158: 127-137. PMID: 14757604

Physical State :
Solid
Solubility :
Soluble in water (Slightly), DMSO, and 0.5 M HCl (50 mg/ml).
Storage :
Store at 4° C
Melting Point :
215° C
Boiling Point :
~413.1° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α25/D -51°±1°, c = 2 in 0.5 M HCl; α20/D -51°±2°, c = 4 in 1mol/L HCl
IC50 :
Adrenergic receptor alpha-2: IC50 = 8 nM (human); Adrenergic receptor alpha: IC50 = 17 nM (rat); β2-AR: IC50 = 284 nM (human); α 1D-AR: IC50 = 449 nM (human); α 2A-AR: IC50 = 737 nM (human)
Ki Data :
Adrenergic receptor alpha-2: Ki= 5 nM (human); Adrenergic receptor alpha-2: Ki= 13 nM (rat); β2-AR: Ki= 196 nM (human); Adrenergic receptor alpha-1: Ki= 200 nM (rat); α 1D-AR: Ki= 221 nM (human)
pK Values :
pKa: 9.6 (Predicted), pKb: 9.16 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DO2625000
PubChem CID :
Merck Index :
14: 3619
MDL Number :
MFCD00002204
EC Number :
200-098-7
Beilstein Registry :
2368277
SMILES :
CNC[[email protected]@H](C1=CC(=C(C=C1)O)O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Su et al Su et al. (PubMed ID 26363772) found that increased epinephrine levels as a result of elevated prenatal maternal stress resulted in newborns having significantly lower birth weights and smaller head circumferences. -SCBT Publication Review
Date published: 2015-07-10
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