Epigenetic Multiple Ligand is a cell-permeable bis-arylidene compound that acts as an epi-ML and inhibits substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1, with weak effect on the process of Np13p by PRMT1. Epigenetic Multiple Ligand has been shown to induce either apoptosis or granulocytic differentiation among U937 cell population. It is an inhibitor of PRMT.
1. Mai, Antonello., et al., 2008. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. Journal of medicinal chemistry. 51(7): 2279-90. PMID: 18348515
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