Epigenetic Multiple LigandA cell-permeable bis-arylidene compound

Epigenetic Multiple Ligand (CAS 1020399-52-3)

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Synonym: PRMT Inhibitor IV
Application: A cell-permeable bis-arylidene compound
CAS Number: 1020399-52-3
Molecular Weight: 623.9
Molecular Formula: C19H12Br4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Epigenetic Multiple Ligand is a cell-permeable bis-arylidene compound that acts as an epi-ML and inhibits substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1, with weak effect on the process of Np13p by PRMT1. Epigenetic Multiple Ligand has been shown to induce either apoptosis or granulocytic differentiation among U937 cell population. It is an inhibitor of PRMT.


References

1. Mai, Antonello., et al., 2008. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. Journal of medicinal chemistry. 51(7): 2279-90. PMID: 18348515

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at 4° C
Boiling Point :
615.56° C at 760 mmHg (Predicted)
Density :
2.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
RmtA: IC50 = 29 µM (Emericella nidulans)
pK Values :
pKa: 5.94 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24827562
SMILES :
C\1OC/C(=C\C2=CC(=C(C(=C2)Br)O)Br)/C(=O)/C1=C/C3=CC(=C(C(=C3)Br)O)Br

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Certificate of Analysis

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