AMI-5 is an inhibitor of protein arginine N-methyltransferases (PRMTs). AMI-5 is described to inhibit PRMT1 (IC50 = 1.41 μM) and Hmt1p (IC0.78 = μM). PRMT1 is known to methylate histone H4, and is essential for other subsequent histone modifications. AMI-5 is also described to inhibit the lysine methyltransferases DOT1L1 (DOT1) and SET7, suggested to correlate with the observation that AMI-5 competitively inhibits binding of AdoMet at Hmt1p.
1. Cheng, D., et al. 2004. J. Biol. Chem. 279: 23892-23899. PMID: 15056663
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MarinicMarinic, et al. (PubMed ID 26188278) tested three irradiation protocols on eosin Y and its subsequent effectiveness in inactivating Enterococcus faecalis biofilms, in vitro. -SCBT Publication Review
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