Eosin Y Disodium TrihydrateAn inhibitor of PRMTs

Eosin Y Disodium Trihydrate (CAS 17372-87-1)

Eosin Y Disodium Trihydrate | CAS 17372-87-1 is rated 5.0 out of 5 by 1.
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Synonym: Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate
Application: An inhibitor of PRMTs
CAS Number: 17372-87-1
Purity: >90%
Molecular Weight: 745.9
Molecular Formula: C20H6Br4O52Na*3H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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AMI-5 is an inhibitor of protein arginine N-methyltransferases (PRMTs). AMI-5 is described to inhibit PRMT1 (IC50 = 1.41 μM) and Hmt1p (IC0.78 = μM). PRMT1 is known to methylate histone H4, and is essential for other subsequent histone modifications. AMI-5 is also described to inhibit the lysine methyltransferases DOT1L1 (DOT1) and SET7, suggested to correlate with the observation that AMI-5 competitively inhibits binding of AdoMet at Hmt1p.


References

1. Cheng, D., et al. 2004. J. Biol. Chem. 279: 23892-23899. PMID: 15056663

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at 4° C
Density :
1.02 g/cm3
IC50 :
Hmt1p: IC50 = 0.78 µM (yeast); PRMT1: IC50 = 1.41 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
LM5850000
PubChem CID :
11048
EC Number :
241-409-6
SMILES :
C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]

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Certificate of Analysis

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Eosin Y Disodium Trihydrate  Product Citations

See how others have used Eosin Y Disodium Trihydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26622543  Liu, C. et al. 2015. Oncol Lett. 10: 619-624.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Marinic Marinic, et al. (PubMed ID 26188278) tested three irradiation protocols on eosin Y and its subsequent effectiveness in inactivating Enterococcus faecalis biofilms, in vitro. -SCBT Publication Review
Date published: 2015-07-02
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