Enniatin BCAS: 917-13-5
MF: C33H57N3O9
MW: 639.82
An ionophore antibiotic that inhibits ACAT and PDE.

Enniatin B (CAS 917-13-5)

Enniatin B | CAS 917-13-5 is rated 5.0 out of 5 by 1.
  • y_2020, m_1, d_17, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202150, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 154ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 3-N-Methylvaline Enniatin; (3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-3,6,9,12,15, 18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8, 11,14,17-hexone
Application: An ionophore antibiotic that inhibits ACAT and PDE
CAS Number: 917-13-5
Purity: 90% (HPLC)
Molecular Weight: 639.82
Molecular Formula: C33H57N3O9
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Enniatin B is an ionophore antibiotic and fungal metabolite generated by multiple Fusarium strains. Studies indicate that Enniatin B has cytotoxic activity in vitro, but no genotoxic activity. Enniatin B has been shown to inhibit the Pdr5p ABC transporter in Saccharomyces cerevisiae, as well as acyl-CoA-cholesterol acyltransferase (ACAT). Additionally, joint studies of valinomycin (sc-200991) and enniatin B have demonstrated that they can bind to calmodulin (CaM) and inhibit the activity of 3',5'-cyclic nucleotide phosphodiesterase (PDE). It is believed that enniatin B possess anticancer properties.


References

1. Mereish, K A., et al., . Interaction of cyclic peptides and depsipeptides with calmodulin. Peptide research. 3(5): 233-7. PMID: 1724618
2. Lifson, S., et al., 1984. Enniatin B and valinomycin as ion carriers: an empirical force field analysis. Journal of biomolecular structure & dynamics. 2(3): 641-61. PMID: 6400917
3. Hiraga, Kazumi., et al., 2005. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and biophysical research communications. 328(4): 1119-25. PMID: 15707993
4. Dornetshuber, Rita., et al., 2007. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Chemical research in toxicology. 20(3): 465-73. PMID: 17326668
5. Behm, Claudia., et al., 2009. The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro. Molecular nutrition & food research. 53(4): 423-30. PMID: 19360736

Physical State :
Solid
Derived From :
Fusarium sp.
Solubility :
Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL), methanol (10 mg/mL), and water (partly).
Storage :
Store at -20° C
Melting Point :
175-175.3° C
Boiling Point :
~827.0° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
Mycobacterium tuberculosis H37Rv: IC50 = 7.26 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
164754
SMILES :
CC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Enniatin B  Product Citations

See how others have used Enniatin B. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22921581  Ficheux, AS. et al. 2012. Toxicon. 60: 1171-9.

PMID: # 9170286  McKee, TC. et al. 1997. J. Nat. Prod. 60: 431-438.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from W tjen W tjen, W. et al. (PubMed 19065580) investigated the toxic effects of Enniatin B on different cancer cell lines. Found that Enniatin B may posses anti-carcinogenic properties by induction of apoptosis and disruption of ERK signaling pathway. -SCBT Publication Review
Date published: 2015-05-19
  • y_2020, m_1, d_17, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202150, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 19ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.