Enniatin A1 is a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for study.
1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann E. et al., Experientia 1947, 3, 202. 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov V.T. Ann. N. Y. Acad. Sci. 1975, 264, 221. 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish K.A. et al., Pept. Res. 1990, 3, 233. 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K. et al., Biochem. Biophys. Res. Commun. 2005, 328, 1119. 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber R. et al., Chem. Res. Toxicol. 2007, 20, 465.
Soluble in water (partly), ethanol (10 mg/ml), methanol (10 mg/ml), DMF, and DMSO (10 mg/ml).
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W tjenW tjen, W. et al. (PubMed 19065580) investigated the toxic effects of Enniatin A1 on different cancer cell lines. Found that Enniatin A1 may posses anti-carcinogenic properties by induction of apoptosis and disruption of ERK signaling pathway. -SCBT Publication Review
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