Enniatin A1A Fusarium sp. derived enniatin

Enniatin A1 (CAS 4530-21-6)

Enniatin A1 | CAS 4530-21-6 is rated 5.0 out of 5 by 1.
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Synonym: 2-(N-Methyl-L-valine) Enniatin A
Application: A Fusarium sp. derived enniatin
CAS Number: 4530-21-6
Purity: >99%
Molecular Weight: 667.87
Molecular Formula: C35H61N3O9
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Enniatin A1 is a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for study.


References

1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann E. et al., Experientia 1947, 3, 202. 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov V.T. Ann. N. Y. Acad. Sci. 1975, 264, 221. 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish K.A. et al., Pept. Res. 1990, 3, 233. 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K. et al., Biochem. Biophys. Res. Commun. 2005, 328, 1119. 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber R. et al., Chem. Res. Toxicol. 2007, 20, 465.

Appearance :
Powder
Physical State :
Solid
Derived From :
Fusarium sp.
Solubility :
Soluble in water (partly), ethanol (10 mg/ml), methanol (10 mg/ml), DMF, and DMSO (10 mg/ml).
Storage :
Store at 4° C
Boiling Point :
~844.5° C at 760 mmHg (Predicted)
Density :
~1.02 g/cm3 (Predicted)
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
Candida albicans: IC50 = 2 µg/ml; Filobasidiella neoformans: IC50 = 4.5 µg/ml (Cryptococcus neoformans); Mycobacterium intracellulare: IC50 = 9 µg/ml
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16727692
MDL Number :
MFCD14635385
SMILES :
CCCC[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)C(C)CC)C)C(C)C)C(C)C)C)C(C)C

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Certificate of Analysis

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Enniatin A1  Product Citations

See how others have used Enniatin A1. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 9170286  McKee, TC. et al. 1997. J. Nat. Prod. 60: 431-438.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from W tjen W tjen, W. et al. (PubMed 19065580) investigated the toxic effects of Enniatin A1 on different cancer cell lines. Found that Enniatin A1 may posses anti-carcinogenic properties by induction of apoptosis and disruption of ERK signaling pathway. -SCBT Publication Review
Date published: 2015-03-06
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