Anti-Endoglin/CD105 Antibody (P4A4)recommended for detection of Endoglin dimer under non-reducing conditions, and Endoglin monomer under reducing conditions of mouse, rat and human origin by WB, IP and IF
Endoglin/CD105 Antibody (P4A4) is a mouse monoclonal IgG2b κ, cited in 13 publications, provided at 200 µg/ml
raised against Endoglin of human origin
Anti-Endoglin/CD105 Antibody (P4A4) is recommended for detection of Endoglin dimer under non-reducing conditions, and Endoglin monomer under reducing conditions of mouse, rat and human origin by WB, IP and IF
Anti-Endoglin/CD105 Antibody (P4A4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also provided azide free for activation of T cell binding to endothelium, sc-20072 L, 200 µg/0.1 ml
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Endoglin/CD105 (P4A4): sc-20072.
m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Endoglin/CD105 Antibody (P4A4) for WB applications. These reagents are now offered in bundles with Endoglin/CD105 Antibody (P4A4) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by vascular abnormalities such as dilated vessels, hemorrhages, liver and lung congestion, and brain or heart ischemia. Mutations in two genes, Endoglin (also designated CD105) and ALK-1 (Activin receptor-like kinase 1, also designated TGFβ superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFβ receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFβ superfamily via association with the respective ligand binding receptors for TGFβ1, TGFβ3, Activin-A, BMP-2 and BMP-7. The human ALK-1 gene encodes two protein species which exist as a result of either glycosylation or alternative splicing events. ALK-1 preferentially binds TGFβ1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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