Anti-Endoglin/CD105 Antibody (P3D1) is a mouse monoclonal IgG2a κ Endoglin/CD105 antibody, cited in 29 publications, provided at 200 µg/ml
raised against Endoglin of human origin
Anti-Endoglin/CD105 Antibody (P3D1) is recommended for detection of TGF-Receptor III complex (known also as Endoglin or CD105) of Endoglin of mouse, rat and human origin by WB, IP, IF and FCM
Anti-Endoglin/CD105 Antibody (P3D1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Endoglin/CD105 (P3D1): sc-18838.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Endoglin/CD105 Antibody (P3D1). This work is in progress.
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Endoglin Antibody (P3D1) is a high quality monoclonal Endoglin antibody (also designated CD105 antibody, or soluble endoglin antibody) suitable for the detection of the Endoglin protein of mouse, rat and human origin. Endoglin Antibody (P3D1) is available as both the non-conjugated anti-Endoglin antibody form, as well as multiple conjugated forms of anti-Endoglin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by vascular abnormalities such as dilated vessels, hemorrhages, liver and lung congestion, and brain or heart ischemia. Mutations in two genes, Endoglin (also designated CD105) and ALK-1 (Activin receptor-like kinase 1, also designated TGFβ superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFβ receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFβ superfamily via association with the respective ligand binding receptors for TGFβ1, TGFβ3, Activin-A, BMP-2 and BMP-7. The human ALK-1 gene encodes two protein species which exist as a result of either glycosylation or alternative splicing events. ALK-1 preferentially binds TGFβ1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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