EmtricitabineCAS: 143491-57-0
MF: C8H10FN3O3S
MW: 247.25
An HIV-1 reverse transcriptase (HIV-1 RT) inhibitor.

Emtricitabine (CAS 143491-57-0)

Emtricitabine | CAS 143491-57-0 is rated 5.0 out of 5 by 1.
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Synonym: Coviracil
Application: An HIV-1 reverse transcriptase (HIV-1 RT) inhibitor
CAS Number: 143491-57-0
Purity: ≥98%
Molecular Weight: 247.25
Molecular Formula: C8H10FN3O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Emtricitabine is a nucleoside analogue which inhibits the reverse nucleoside transcriptase enzyme. Structurally this antiviral agent is similar to Lamivudine. This agent is effective at targeting HIV and HBV viruses since these viruses replicate in a reverse transcriptase manner. Studies indicate that the structure of Emtricitabine, specifically the unnatural β-L structural configuration produce greater antiviral effects in vitro on HIV and HBV than other antiviral agents. To activate Emtricitabine it needs to undergo multistep intracellular phosphorylation by various cellular kinases. These studies suggest that Emtricitabine competitively inhibits HIV-1 RT (HIV-1 reverse transcriptase) and can cause termination of DNA chain elongation in the virus via incorporation into the viral genome.


References

1. Darque, A., et al. 1999. Antimicrob. Agents Chemother. 43: 2245-2250. PMID: 10471573
2. Das, K., et al. 2001. J. Virol. 75: 4771-4779. PMID: 11312349
3. Dando, T.M. and Wagstaff, A.J. 2004. Drugs. 64: 2075-82. PMID: 15341498

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (≥ 50 mg/ml), water (≥ 50 mg/ml), and ethanol (≥ 17 mg/ml).
Storage :
Store at -20° C
Melting Point :
153-155° C
Boiling Point :
~443.3° C at 760 mmHg (Predicted)
Density :
~1.8 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60877
SMILES :
C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F

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Emtricitabine  Product Citations

See how others have used Emtricitabine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24487230  Thein, P. et al. 2014. Hear. Res. 310: 27-35.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Dando et al Dando et al. (PubMed ID 15341498) used the analog reverse transcriptase inhibitor, Emtricitabine, to treat HIV and found it to reduce HIV RNA levels and increase CD4+ cell counts. -SCBT Publication Review
Date published: 2015-06-30
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