Emodin CAS: 518-82-1
MF: C15H10O5
MW: 270.24

Emodin (CAS 518-82-1)

Emodin | CAS 518-82-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione
Application: Emodin is a potent Lck tyrosine kinase inhibitor shown to suppress Neu tyrosine kinase activity
CAS Number: 518-82-1
Purity: ≥95%
Molecular Weight: 270.24
Molecular Formula: C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Emodin is a potent Lck (p56lck tyrosine kinase) inhibitor (IC50 = 18.5 μM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 μM). Emodin has been shown to suppress HER2/Neu tyrosine kinase activity in HER2/Neu overexpressing breast cancer cells. Emodin is an inhibitor of casein kinase.


References

1. Jayasuriya, H., et al. 1992. J. Nat. Prod. 55: 696-698. PMID: 1517743

2. Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193: 1152-1158. PMID: 7686746

3. Zhang, L., et al. 1996. Oncogene. 12: 571-576. PMID: 8637714

4. Pickhardt, M., et al. 2005. J. Biol. Chem. 280: 3628-3635. PMID: 15525637

Physical State :
Solid
Derived From :
Frangula bark
Solubility :
Soluble in ethanol, sodium carbonate solution, DMSO (1 mg/ml), aqueous alkali, 1eq. NaOH (100 mM), ammonium hydroxide (10 mg/ml), ether, chloroform, benzene , and THF. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
256-257° C
Boiling Point :
586.87° C at 760 mmHg (Predicted)
Density :
1.58 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
p56lck tyrosine kinase: IC50 = 18.5 µM; growth of v-ras transformed human bronchial epithelial cells: IC50 = 15 µM; Casein kinase II beta: IC50 = 460 nM (human); Casein kinase II alpha: IC50 = 460 nM (human); HEK293 : IC50 = 1.3 µM (human); Estrogen receptor alpha: IC50 = 2.7 µM (human); Protein-tyrosine phosphatase 4A3: IC50 = 3.5 µM (human); HCT-116: IC50 = 3.8 µM (human); HepG2 : IC50 = 5.2 µM (human); Dengue virus 2: EC5050 = 10.9 µM
Ki Data :
Estrogen receptor alpha: Ki= 0.77 µM (human); Estrogen receptor beta: Ki= 1.5 µM (human); Casein kinase II alpha: Ki= 1.85 µM (human)
pK Values :
pKa: 6.39
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB7920600
PubChem CID :
Merck Index :
14: 3561
MDL Number :
MFCD00001207
EC Number :
208-258-8
Beilstein Registry :
1888141
SMILES :
CC1=CC2=C(C(O)=C1)C(=O)C1=C(C=C(O)C=C1O)C2=O

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Certificate of Analysis

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Emodin (CAS 518-82-1)  Product Citations

See how others have used Emodin (CAS 518-82-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24894567  Omar, JM.|Yang, H.|Li, S.|Marquardt, RR.|Jones, PJ.| et al. 2014. J Agric Food Chem. 62: 5812-7.

PMID: # 24358188  Lee, YS. et al. 2013. PloS one. 8: e82479.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from A slight A slight, but noticeable decrease in Mcl-1 protein expression observed by WB when comparing untreated U266 cells with those that have been treated with Emodin. -SCBT QC
Date published: 2015-02-08
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