EMD 386088 hydrochlorideA potent SR-6 agonist

EMD 386088 hydrochloride (CAS 54635-62-0)

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Synonym: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
Application: A potent SR-6 agonist
CAS Number: 54635-62-0
Purity: ≥99%
Molecular Weight: 283.2
Molecular Formula: C14H15N2Cl•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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EMD 386088 hydrochloride is a potent SR-6 (5-HT6) receptor agonist (EC50 = 1.0 nM) that displays selectivity to other serotonin receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for SR-6, SR-1D(5-HT1D), SR-1B(5-HT1B), SR-2A(5-HT2A), SR-2C, SR-4, SR-1A and SR-7, respectively). Moderate affinity at SR-3 (IC50 = 34 nM).


References

1. Mattsson, C., et al. 2005. Bioorg. Med. Chem. Lett. 15: 4230-4234.

Physical State :
Solid
Solubility :
Soluble in water (25 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
5-HT6 receptor: IC50 = 7.4 nM; 5-HT3 receptor: IC50 = 34 nM; 5-HT1D receptor: IC50 = 110 nM; 5-HT1B receptor: IC50 = 180 nM; 5-HT2A receptor: IC50 = 240 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972198
MDL Number :
MFCD09038557
SMILES :
CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl

Download SDS (MSDS)

Certificate of Analysis

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