Embelin, a cell permeable 1,4-Benzoquinone (sc-202873)-derivative originally isolated from Embelia ribes, has been shown to contain antiproliferative characteristics in 3-Methylcholanthrene (sc-216516)-induced fibrosarcoma in albino rats. This compound has also been reported to be an antinociceptive and antiinflammatory agent. Additionally, Embelin has been found to display antibacterial potential against 3 strains of 12 bacteria. Other studies have reported Embelin to have apoptosis induction capabilities through binding of BIR3 domain of XIAP (X-linked inhibitor of apoptosis protein). The antioxidant capabilities of Embelin have also been studied and mechanistic studies suggest that Embelin has a tendency to scavenge DPPH (sc-202591) radicals and inhibit hydroxyl radical induced deoxyribose degradation. This compound prevents the activation of NF-κB by inhibiting IKK. Embelin is an inhibitor of PCAF and XIAP and an activator of caspase-9.
1. Chitra, M., et al. 1994. Chemotherapy. 40: 109-113. PMID: 7510605 2. Chitra, M., et al. 2003. Fitoterapia. 74: 401-403. PMID: 12781816 3. Nikolovska-Coleska, Z., et al. 2004. J. Med. Chem. 47: 2430-2440. PMID: 15115387 4. Joshi, R., et al. 2007. Chem. Biol. Interact. 167: 125-134. PMID: 17379198
Soluble in DMSO (>10 mg/ml), methanol, ethanol (10 mM), and chloroform. Insoluble in water.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Date published: 2015-10-08
Rated 5 out of
HuangHuang, et. al. (PubMed ID 23749209) treated HCT116 cells with Embelin (purchased from SCBT) and found that it enhanced both conversion of LC3-I to LC3-II and formation of GFP-LC3 puncta in a dose and time dependent manner. However, it failed to enhance autophagy in HCT116 XIAP KO cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.