Eicosapentaenoic Acid-d5 is a deuterated ω-3 fatty acid abundantly available in marine organisms and is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. It is intended for use as an internal standard for the quantification of EPA by GC- or LC-mass spectrometry. Eicosapentaenoic Acid-d5 is also an inhibitor of 5-LO.
1 Wada, M., DeLong, C.J., Hong, Y.H., et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282(31) 22254-22266 (2007). 2 Yerram, N.R., Moore, S.A., Spector, A.A. Eicosapentaenoic acid metabolism in brain microvessel endothelium: Effect on prostaglandin formation. J Lipid Res 30 1747-1757 (1989). 3 Takeuchi, H., Inoue, J., Yoshida, M., et al. Dietary effects of n-3 eicosapentaenoic acid on essential fatty acid-deficiency symptoms of rats. Agric Biol Chem 53 3225-3232 (1989).
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