Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3)CAS: 10417-94-4
MF: C20H30O2
MW: 302.45
A 5-LO inhibitor.

Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) (CAS 10417-94-4)

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Synonym: Eicosapentaenoic Acid; Icosapent
Application: A 5-LO inhibitor
CAS Number: 10417-94-4
Purity: ≥98%
Molecular Weight: 302.45
Molecular Formula: C20H30O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) (EPA), an ω-3 fatty acid, has been reported to act as a precursor to thromboxanes and prostaglandins (PG). EPA inhibits amino acid oxygenation by PG endoperoxide H synthase-1 and 5-LO (5-lipoxygenase). Experiments have demonstrated the ability of EPA to increase Cafestol palmitate (sc-205613) incorporation into the lipid fraction and decrease the rate of fatty acid oxidation in murine adipose tissue. Additionally, this agent has demonstrated the ability to cause a decrease in gene expression for IL-6 and TNF-α both in skeletal muscle and adipose tissue.


1. Yerram, N.R., et al. 1989. J. Lipid Res. 30: 1747-1757. PMID: 2559136
2. Roth, H.P. and Kirchgessner, M. 1992. Ann. Nutr. Metab. 36: 113-120. PMID: 1354951
3. Wada, M., et al. 2007. J. Biol. Chem. 282: 22254-22266. PMID: 17519235
4. Figueras, M., et al. 2010. Obesity. [Epub ahead of print]. PMID: 20885391

Appearance :
Physical State :
Solubility :
Soluble in ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), chloroform, ethyl acetate, and methanol.
Storage :
Store at -20° C
Melting Point :
-54--53° C (lit.)
Boiling Point :
~439.30° C at 760 mmHg (Predicted)
Density :
~0.9 g/mL (Predicted)
Refractive Index :
n20D 1.50 (lit.)
IC50 :
mPGES1: IC50 = 300 nM; Cyclooxygenase-2: IC50 = 7100 nM (Ovis aries)
pK Values :
pKa: 4.75
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 3531
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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