Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3)CAS: 10417-94-4
MF: C20H30O2
MW: 302.45
A 5-LO inhibitor.

Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) (CAS 10417-94-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 152ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Eicosapentaenoic Acid; Icosapent
Application: A 5-LO inhibitor
CAS Number: 10417-94-4
Purity: ≥98%
Molecular Weight: 302.45
Molecular Formula: C20H30O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) (EPA), an ω-3 fatty acid, has been reported to act as a precursor to thromboxanes and prostaglandins (PG). EPA inhibits amino acid oxygenation by PG endoperoxide H synthase-1 and 5-LO (5-lipoxygenase). Experiments have demonstrated the ability of EPA to increase Cafestol palmitate (sc-205613) incorporation into the lipid fraction and decrease the rate of fatty acid oxidation in murine adipose tissue. Additionally, this agent has demonstrated the ability to cause a decrease in gene expression for IL-6 and TNF-α both in skeletal muscle and adipose tissue.


References

1. Yerram, N.R., et al. 1989. J. Lipid Res. 30: 1747-1757. PMID: 2559136
2. Roth, H.P. and Kirchgessner, M. 1992. Ann. Nutr. Metab. 36: 113-120. PMID: 1354951
3. Wada, M., et al. 2007. J. Biol. Chem. 282: 22254-22266. PMID: 17519235
4. Figueras, M., et al. 2010. Obesity. [Epub ahead of print]. PMID: 20885391

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), chloroform, ethyl acetate, and methanol.
Storage :
Store at -20° C
Melting Point :
-54--53° C (lit.)
Boiling Point :
~439.30° C at 760 mmHg (Predicted)
Density :
~0.9 g/mL (Predicted)
Refractive Index :
n20D 1.50 (lit.)
IC50 :
mPGES1: IC50 = 300 nM; Cyclooxygenase-2: IC50 = 7100 nM (Ovis aries)
pK Values :
pKa: 4.75
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JX3820000
PubChem CID :
446284
Merck Index :
14: 3531
MDL Number :
MFCD00065716
EC Number :
600-528-7
Beilstein Registry :
1714433
SMILES :
CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 116ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.