EGFR Inhibitor III is a cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation while having no effect on the expression levels of EGFR. It suppresses leiomyoma and myometrical cell proliferation. EGFR Inhibitor III has been shown to induce apoptosis and cell cycle arrest. In combination with Genistein (sc-3515), the compound can completely suppress leiomyoma cell proliferation.
Shushan, A., et al. 2007. Fertil. Steril. 87, 127.
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