EGFR Inhibitor IIIInhibits EGFR- kinase activity, blocking phosphorylation

EGFR Inhibitor III (CAS 733009-42-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 51ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: N-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
Application: Inhibits EGFR- kinase activity, blocking phosphorylation
CAS Number: 733009-42-2
Molecular Weight: 399.6
Molecular Formula: C16H10Cl3FN4O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

EGFR Inhibitor III is a cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation while having no effect on the expression levels of EGFR. It suppresses leiomyoma and myometrical cell proliferation. EGFR Inhibitor III has been shown to induce apoptosis and cell cycle arrest. In combination with Genistein (sc-3515), the compound can completely suppress leiomyoma cell proliferation.


References

Shushan, A., et al. 2007. Fertil. Steril. 87, 127.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at -20° C
IC50 :
leiomyoma: IC50 = 0.7 µM; myometrical cell proliferation: IC50 = 1.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
118797290
SMILES :
C1=CC2=C(C=C1NC(=O)[C]Cl)C(=NC=N2)NC3=CC(=C(C=C3F)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 68ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 84ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.