EGFR InhibitorA highly selective, cell-permeable EGFR inhibitor

EGFR Inhibitor (CAS 879127-07-8)

EGFR Inhibitor | CAS 879127-07-8 is rated 5.0 out of 5 by 1.
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Synonym: Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
Application: A highly selective, cell-permeable EGFR inhibitor
CAS Number: 879127-07-8
Molecular Weight: 413.4
Molecular Formula: C21H18F3N5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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EGFR Inhibitor is a cell permeable compound that is a highly selective inhibitor of EGFR (epidermal growth factor receptor). Inhibition of EGFR has been shown to induce apoptosis. Mechanistic studies have shown that EGFR inhibition takes place via downregulation of antiapoptotic protein survivin expression. Downregulation of Survivin has been observed to take place following inhibition of the PI3K-AKT signaling pathway. Additional experiments report that EGFR inhibitors also induce upregulation of proapoptotic protein BIM.


References

1. Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128: 2182-2183. PMID: 16478150

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -20° C
IC50 :
EGFRwt: IC50 = 21 nM; EGFRL858R: IC50 = 63 nM; EGFRL861Q: IC50 = 4 nM; erbB4/Her4 : IC50 = 7.64 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9549299
SMILES :
C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from EGFR Inhibitor was reported in many articles EGFR Inhibitor was reported in many articles as a very potent EGFR tyrosine kinase inhibitor. -SCBT Publication Review
Date published: 2015-04-28
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