EGFR Inhibitor is a cell permeable compound that is a highly selective inhibitor of EGFR (epidermal growth factor receptor). Inhibition of EGFR has been shown to induce apoptosis. Mechanistic studies have shown that EGFR inhibition takes place via downregulation of antiapoptotic protein survivin expression. Downregulation of Survivin has been observed to take place following inhibition of the PI3K-AKT signaling pathway. Additional experiments report that EGFR inhibitors also induce upregulation of proapoptotic protein BIM.
1. Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128: 2182-2183. PMID: 16478150
Soluble in DMSO (50 mg/ml), and ethanol (25 mg/ml).
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.