Efaroxan hydrochlorideCAS: 89197-00-2
MF: C13H16N2O•HCl
MW: 252.74
A potent α2-AR adrenoceptor antagonist.

Efaroxan hydrochloride (CAS 89197-00-2)

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Application: A potent α2-AR adrenoceptor antagonist
CAS Number: 89197-00-2
Purity: ≥99%
Molecular Weight: 252.74
Molecular Formula: C13H16N2O•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Efaroxan hydrochloride promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3 receptor) in vitro. Efaroxan hydrochloride is a potent, highly selective α2-AR adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α2A-AR , α2B-AR , α2C-AR , Ι1 and Ι2 receptors, respectively).


References

1. Chapleo, C.B., et al. 1984. J. Med. Chem. 27: 570-576.
2. Olmos, G., et al. 1994. Eur. J. Pharmacol. 262: 41-48.
3. Eglen, R,.M., et al. 1998. Trends Pharmacol Sci. 19: 381-390.
4. Mayer, G. and Taberner, P.V. 2002. Eur. J. Pharmacol. 454: 95.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at 4° C
Melting Point :
249.6° C
Boiling Point :
387° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957548
MDL Number :
MFCD00069270
SMILES :
CCC1(CC2=CC=CC=C2O1)C3=NCCN3.Cl

Download SDS (MSDS)

Certificate of Analysis

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