EchinosporinAn apoptotic cell-cycle inhibitor

Echinosporin (CAS 79127-35-8)

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Synonym: (1S,4aS,5S,7aS)-5-Hydroxy-8-oxo-1,4a,5,7a-tetrahydro-1,5-(epoxymethano)cyclopenta[c] pyran-3-carboxamide
Application: An apoptotic cell-cycle inhibitor
CAS Number: 79127-35-8
Molecular Weight: 223.18
Molecular Formula: C10H9NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Echinosporin inhibits the cell cycle at the G(2)/M phase and induces apoptosis. It is both antitumor and antibiotic.


References

1. Morimoto, M., et al., 1985. Antitumor activity of echinosporin. The Journal of antibiotics. 38(4): 490-5. PMID: 4008342
2. Sato, T., et al., 1982. A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization. The Journal of antibiotics. 35(3): 266-71. PMID: 7076574
3. Cui, C B., et al., 2007. Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus. Fitoterapia. 78(3): 238-40. PMID: 17376609

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
dimethyl formamide, methanol or water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
72542
SMILES :
C1=C[C@@]2([C@@H]3[C@@H]1[C@@H](OC(=C3)C(=O)N)OC2=O)O

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Certificate of Analysis

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