EC 23 CAS: 104561-41-3
MF: C23H24O2
MW: 332.44
EC 23 is an ATRA analog with similar activity.

EC 23 (CAS 104561-41-3)

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Alternate Names: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid
Application: EC 23 is an ATRA analog with similar activity
CAS Number: 104561-41-3
Purity: ≥98%
Molecular Weight: 332.44
Molecular Formula: C23H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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EC 23 potently induces neural differentiation in human pluripotent embryonic stem cells.


References

Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497. Barnard et al (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15 11430. Maltman et

Physical State :
Solid
Solubility :
Soluble in DMSO (10mg/ml). Limited solubility in water or 95% ethanol (0.33mg/ml); vortex to dissolve.
Storage :
Store at room temperature
Melting Point :
194.16° C (Predicted)
Boiling Point :
~484.7° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Retinoic acid receptor alpha: EC5050 = 0.6 nM (human); Retinoic acid receptor gamma: EC5050 = 0.6 nM (human); Retinoic acid receptor beta: EC5050 = 0.3 nM (human)
pK Values :
pKa: 4.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD18086921
SMILES :
CC1(CCC(C2=C1C=CC(=C2)C#CC3=CC=C(C=C3)C(=O)O)(C)C)C

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EC 23 (CAS 104561-41-3)  Product Citations

See how others have used EC 23 (CAS 104561-41-3). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 34440786  Choi, H.|Shinohara, M.|Ibuki, M.|Nishikawa, M.|Sakai, Y.| et al. 2021. Cells. 10:

PMID: # 31145732  Yabe, SG.|Nishida, J.|Fukuda, S.|Takeda, F.|Nasiro, K.|Yasuda, K.|Iwasaki, N.|Okochi, H.| et al. 2019. PLoS ONE. 14: e0217110.

PMID: # 30623004  Yabe, SG.|Fukuda, S.|Nishida, J.|Takeda, F.|Nashiro, K.|Okochi, H.| et al. 2019. Regen Ther. 10: 69-76.

PMID: # 27038181  Yabe, SG. et al. 2017. J Diabetes. 9: 168-179.

PMID: # 33428669  PLoS One. e0245204.

Citations 1 to 5 of 5 total
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