EbselenAn inhibitor of 5-LO, 15-LO, Cox, NADPH, and NADPH oxidase

Ebselen (CAS 60940-34-3)

Ebselen | CAS 60940-34-3 is rated 5.0 out of 5 by 1.
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Synonym: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one; Harmokisane
Application: An inhibitor of 5-LO, 15-LO, Cox, NADPH, and NADPH oxidase
CAS Number: 60940-34-3
Purity: ≥98%
Molecular Weight: 274.18
Molecular Formula: C13H9NOSe
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ebselen is an interesting organoselenium compound displaying antiinflammatory and antioxidant properties. Ebselen is shown to inhibit the 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) enzymes in the absence of glutathione. Ebselen also inhibits Cox (cyclooxygenase), PKC (protein kinase C), DECR1 (NADPH), and Mox-1 (NADPH oxidase). The oxidation of low density lipoproteins by free radicals is suppressed by the antioxidant action of Ebselen. Ebselen is an inhibitor of Cox-1, Cox-2, NOS, GST and IDO.


References

1. Nikawa, T., et al. 1994. Biochem. Pharmacol. 47: 1007-1012. PMID: 8147899
2. Schewe, C., et al. 1994. Biochem. Pharmacol. 48: 65-74. PMID: 8043032
3. Noguchi, N., et al. 1994. Biochim. Biophys. Acta. 1213: 176-182. PMID: 8025128

Physical State :
Solid
Solubility :
Soluble in PBS pH7.2, DMSO (25 mg/ml), ethanol (10 mg/ml), methanol, acetone, acetonitrile, and DMF (~5 mg/ml).
Storage :
Store at room temperature
Melting Point :
180-181° C
Boiling Point :
~402.8° C at 760 mmHg (Predicted)
IC50 :
Trypanosoma brucei: EC5050 = 4100 nM; CHO-K1 (Ovarian cells): EC5050 = 6100 nM (Cricetulus griseus); Streptococcus sp. ′group A′: EC5050 = 1096 nM; Streptococcus: EC5050 = 975 nM; Streptokinase A: EC5050 = 1519 nM (Streptococcus pyogenes serotype M1); UDP-glucose 4-epimerase: IC50 = 14 nM (human); Mannose-6-phosphate isomerase: IC50 = 190 nM (human); Perilipin-5: IC50 = 1101 nM (human); Phosphomannomutase 2: IC50 = 672 nM (human); Phosphoethanolamine/phosphocholine phosphatase: IC50 = 111 nM (human); Mitochondrial import inner membrane translocase subunit TIM10: IC50 = 580 nM (Saccharomyces cerevisiae S288c); HIV-1(RF): IC50 = 13.2 µM (CEM-SS); HIV-1(RF): EC5050 = 2.38 µM (CEM-SS)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DE4140750
PubChem CID :
3194
Merck Index :
14: 3486
MDL Number :
MFCD00210937
Beilstein Registry :
164926
SMILES :
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2

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Ebselen  Product Citations

See how others have used Ebselen. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29600321  Soyman, Z.|Uzun, H.|Bayindir, N.|Esrefoglu, M.|Boran, B.| et al. 2018. Arch. Gynecol. Obstet. 297: 1549-1555.

PMID: # 25310738  Makarewicz, D. et al. 2014. Folia Neuropathol. 52: 270-84.

PMID: # 16403691  Sui, H. et al. 2005. Blood Press. 14: 366-372.

PMID: # 11182296  Kono, H. et al. 2001. Free Radic. Biol. Med. 30: 403-411.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Kono Kono, et. al. Utilized 2-phenyl-1,2-benzisoselenazole-3(2H)-one (ebselen) to test their hypothesis that this compound can prevent early alcohol-induced liver injury in rats. -SCBT Publication Review
Date published: 2015-03-29
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