Ebselen is an organoselenium compound that displays anti-inflammatory and antioxidant properties. Ebselen is shown to modify cysteine residues and inhibit the 5-LO (5-lipoxygenase) and 15-LO enzymes in the absence of glutathione. Ebselen also inhibits protein kinase C, cyclooxygenases Cox-1 and Cox-2, NOS (Nitric oxide synthase), GST (glutathione S-transferase), IDO (Indoleamine-pyrrole 2,3-dioxygenase), NADPH (nicotinamide adenine dinucleotide phosphate oxidase), and NADPH oxidase. The oxidation of low density lipoproteins by free radicals is suppressed by the antioxidant action of Ebselen.
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Soluble in PBS pH7.2, DMSO (25 mg/ml), ethanol (10 mg/ml), methanol, acetone, acetonitrile, and DMF (~5 mg/ml).
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KonoKono, et. al. Utilized 2-phenyl-1,2-benzisoselenazole-3(2H)-one (ebselen) to test their hypothesis that this compound can prevent early alcohol-induced liver injury in rats. -SCBT Publication Review
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