Ebelactone ACAS: 76808-16-7
MF: C20H34O4
MW: 338.48
An inhibitor of esterase, formyl methionine aminopeptidase, and acylpeptide hydrolase.

Ebelactone A (CAS 76808-16-7)

Ebelactone A | CAS 76808-16-7 is rated 5.0 out of 5 by 1.
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Synonym: 3,11-Dihydroxy-2,4,6,8,10,12-hexamethyl-9-oxo-6-tetradecenoic acid 1,3-lactone
Application: An inhibitor of esterase, formyl methionine aminopeptidase, and acylpeptide hydrolase
CAS Number: 76808-16-7
Purity: ≥99%
Molecular Weight: 338.48
Molecular Formula: C20H34O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ebelactone A is a product of anctinomycetes that acts as an esterase inhibitor. Studies suggest that Ebelactone A is a formyl methionine aminopeptidase inhibitor. Additionally, at low concentrations, this compound has been observed to act as a covalent and irreversible inhibitor of APEH (acylpeptide hydrolase).


References

1. Umezawa, H., et al. 1980. J. Antibiot. 33: 1594-1596. PMID: 7251497
2. Uotani, K., et al. 1982. J. Antibiot. 35: 1495-1499. PMID: 7161188
3. Uotani, K., et al. 1982. J. Antibiot. 35: 1670-1674. PMID: 7166532
4. Scaloni, A., et al. 1992. J. Biol. Chem. 267: 3811-3818. PMID: 1740429

Physical State :
Solid
Derived From :
Microbial
Solubility :
Soluble in water (partly), methanol (10 mg/ml), ethanol, and chloroform.
Storage :
Store at -20° C
Melting Point :
128.07° C (Predicted)
Boiling Point :
~462.8° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.48 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RQ7730000
PubChem CID :
3192
MDL Number :
MFCD00036710
SMILES :
CCC(C)C(C(C)C(=O)C(C)C=C(C)CC(C)C1C(C(=O)O1)C)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Scaloni et al Scaloni et al. (PubMed ID 1740429) used ebalactone A to inhibit erythrocyte acylpeptide hydrolase in order to identify the enzyme s active site. -SCBT Publication Review
Date published: 2015-01-16
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