Ebelactone A is a product of anctinomycetes that acts as an esterase inhibitor. Studies suggest that Ebelactone A is a formyl methionine aminopeptidase inhibitor. Additionally, at low concentrations, this compound has been observed to act as a covalent and irreversible inhibitor of APEH (acylpeptide hydrolase).
1. Umezawa, H., et al. 1980. J. Antibiot. 33: 1594-1596. PMID: 7251497 2. Uotani, K., et al. 1982. J. Antibiot. 35: 1495-1499. PMID: 7161188 3. Uotani, K., et al. 1982. J. Antibiot. 35: 1670-1674. PMID: 7166532 4. Scaloni, A., et al. 1992. J. Biol. Chem. 267: 3811-3818. PMID: 1740429
Soluble in water (partly), methanol (10 mg/ml), ethanol, and chloroform.
Store at -20° C
128.07° C (Predicted)
~462.8° C at 760 mmHg (Predicted)
~1.0 g/cm3 (Predicted)
n20D 1.48 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Certificate of Analysis
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Scaloni et alScaloni et al. (PubMed ID 1740429) used ebalactone A to inhibit erythrocyte acylpeptide hydrolase in order to identify the enzyme s active site. -SCBT Publication Review
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