EB-47 dihydrochloride dihydrateA useful PARP-1 inhibitor for proteomics research

EB-47 dihydrochloride dihydrate

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Application: A useful PARP-1 inhibitor for proteomics research
Purity: ≥95%
Molecular Weight: 646.48
Molecular Formula: C24H27N9O62HCl•2H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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EB-47 dihydrochloride dihydrate is a very potent and water soluble PARP-1 inhibitor. Shows cytoprotective effects against oxidative damage in cell models of reperfusion injury and inflammation.


References

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1): P.G. Jagtap, et al.; Bioorg. Med. Chem. Lett. 14, 81 (2004) Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008)

Physical State :
Solid
Solubility :
Soluble in water, and DMSO.
Storage :
Store at -20° C
Refractive Index :
n20D 1.87 (Predicted)
IC50 :
PARP-1 : IC50 = 45 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
Cl.Cl.O=C(CN1CCN(CC1)C(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)Nc1cccc2C(=O)NCc12.O.O

Download SDS (MSDS)

Certificate of Analysis

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