EB-47 dihydrochloride dihydrate is a very potent and water soluble PARP-1 inhibitor. Shows cytoprotective effects against oxidative damage in cell models of reperfusion injury and inflammation.
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1): P.G. Jagtap, et al.; Bioorg. Med. Chem. Lett. 14, 81 (2004) Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008)
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