EB 1089A vitamin D receptor agonist and potent inhibitor of PTH-rP

EB 1089 (CAS 134404-52-7)

EB 1089 | CAS 134404-52-7 is rated 5.0 out of 5 by 1.
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Synonym: Seocalcitol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
Application: A vitamin D receptor agonist and potent inhibitor of PTH-rP
CAS Number: 134404-52-7
Purity: ≥98%
Molecular Weight: 454.68
Molecular Formula: C30H46O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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EB1089 is an analog of 1,25 dihydroxyvitamin D which acts as a vitamin D receptor (VDR). EB1089 is noted to reverse hypercalcemia and is a potent inhibitor of PTH-rP (parathyroid hormone-related peptide, PTHRP) in vitro. In studies utilizing a squamous cancer cell line, EB1089 was noted to reverse hypercalcemia. Additionally, EB1089 was reported to downregulate PTHRP expression in a prostate cancer cell line, C4-2 and was also noted to augment anchorage-independent cell growth in vitro. Other studies note that EB1089 inihibits the proliferation of HEp-2 cell lines and is reported that p57 has a profound role in this inhibition. Futhermore, EB1089 is also reported to be a noted mitogen of neonatal rat lung fibroblasts.


References

1. Abdaimi, K., et al. 1999. Cancer Res. 59: 3325-3328. PMID: 10416587
2. Lu , L., et al. 2008. Mol. Cancer Ther. 7: 1268-1274. PMID: 18483314
3. Ormerod, A.K., et al. 2008. Exp. Lung. Res. 34: 155-182. PMID: 18432454
4. Bhatia, V., et al. 2009. Mol. Cancer Ther. 8: 1787-1798. PMID: 19584236

Physical State :
Solid
Solubility :
Soluble in DMSO, and ethanol.
Storage :
Store at -20° C
Melting Point :
237.06° C (Predicted)
Boiling Point :
608.47° C at 760 mmHg (Predicted)
Density :
1.07 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
GV0270000
PubChem CID :
6435810
MDL Number :
MFCD00871599
SMILES :
CCC(CC)(/C=C/C=C/[C@@H](C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C/C=C/3\\C[C@H](C[C@@H](C3=C)O)O)C)O

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Certificate of Analysis

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EB 1089  Product Citations

See how others have used EB 1089. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27327272  Bartonkova, I. et al. 2016. Chem. Res. Toxicol.

PMID: # 25641222  Wang, K. et al. 2015. Histopathology. 67: 386-97.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Sharma K; et al Sharma K; et al. (PubMed ID: 25629933) determined that EB 1089 could enhance the response to radiation in A549 and H460. -SCBT Publication Review
Date published: 2015-04-03
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