Anti-dUTPase Antibody (H-9) is a mouse monoclonal IgG3 (kappa light chain) dUTPase antibody provided at 200 µg/ml
specific for an epitope mapping between amino acids 203-219 near the C-terminus of dUTPase of human origin
recommended for detection of dUTPase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine and porcine
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of dUTPase (H-9): sc-166856.
m-IgGκ BP-HRP is the preferred secondary detection reagent for dUTPase Antibody (H-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with dUTPase Antibody (H-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
dUTPase Antibody (H-9) is a high quality monoclonal dUTPase antibody (also designated dUTPase antibody) suitable for the detection of the dUTPase protein of mouse, rat and human origin. dUTPase Antibody (H-9) is available as the non-conjugated anti-dUTPase antibody. dUTPase (deoxyuridine 5′-triphosphate nucleotidohydrolase), also known as DUT or dUTP pyrophosphatase, is a preventive DNA repair enzyme that functions in nucleotide metabolism. dUTPase is expressed in a variety of tissues and, depending on the isoform (DUT-N or DUT-M), localizes to the nucleus or the mitochondrion. The nuclear isoform, DUT-N, is the most abundant of the two isoforms. dUTPase, in the presence of magnesium ions, is responsible for hydrolyzing dUTP to dUMP and diphosphate. This reaction is important for keeping the intracellular dUTP concentration low so that uracil does not become incorporated into DNA. Extensive incorporation of uracil into DNA can ultimately lead to cell death. This suggests that dUTPase is essential for cell viability, further implying that dUTPase is a potential target for anticancer therapy. In addition, dUMP, the product of the hydrolysis reaction, is a precursor of thymidine nucleotides which are essential for DNA replication.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.