dUTPase Antibody (F-6) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 203-219 near the C-terminus of dUTPase of human origin
recommended for detection of dUTPase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for dUTPase Antibody (F-6) for WB applications. These reagents are now offered in bundles with dUTPase Antibody (F-6) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
dUTPase (deoxyuridine 5′-triphosphate nucleotidohydrolase), also known as DUT or dUTP pyrophosphatase, is a preventive DNA repair enzyme that functions in nucleotide metabolism. dUTPase is expressed in a variety of tissues and, depending on the isoform (DUT-N or DUT-M), localizes to the nucleus or the mitochondrion. The nuclear isoform, DUT-N, is the most abundant of the two isoforms. dUTPase, in the presence of magnesium ions, is responsible for hydrolyzing dUTP to dUMP and diphosphate. This reaction is important for keeping the intracellular dUTP concentration low so that uracil does not become incorporated into DNA. Extensive incorporation of uracil into DNA can ultimately lead to cell death. This suggests that dUTPase is essential for cell viability, further implying that dUTPase is a potential target for anticancer therapy. In addition, dUMP, the product of the hydrolysis reaction, is a precursor of thymidine nucleotides which are essential for DNA replication.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.