DuP-697, an anti-inflammatory agent, is an inhibitor of Cox-1 and Cox-2 with 50 fold more selectivity for Cox-2 (IC50 of 10 nM) than for Cox-1 (IC50 of 800 nM). DuP-697 has also demonstrated the ability to reduce the exaggerated release of prostaglandin (PG) E2 elicited by Bradykinin in hydronephrotic kidney cells. Mechanistic studies suggest that DuP-697 interacts reversibly with PG H Synthase-1 while irreversibly inhibiting PGHS-2. Further research shows that DuP-697 suppresses cell growth and induces apoptosis by cell-cycle arrest and caspase-8 activation.
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