DuloxetineAn inhibitor of ST and SLC6A2

Duloxetine (CAS 116539-59-4)

Duloxetine | CAS 116539-59-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_16, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_279011, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 84ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
Application: An inhibitor of ST and SLC6A2
CAS Number: 116539-59-4
Purity: ≥99%
Molecular Weight: 297.42
Molecular Formula: C18H19NOS
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Duloxetine is an ST and SLC6A2 inhibitor (serotonin-norepinephrine reuptake inhibitor/SNRI).

Physical State :
Liquid
Solubility :
Soluble in water (slightly).
Storage :
Store at -20° C
Melting Point :
156.99° C (Predicted)
Boiling Point :
466.2° C at 760 mmHg
Density :
1.16 g/mL
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20D +120.5°±4.5°, c = 1 in methanol
IC50 :
ST: IC50 = 3 nM (human); SLC6A2: IC50 = 4 nM (human); DATSlc6a3: IC50 = 370 nM (human)
Ki Data :
ST: Ki= 0.5 nM (human); rat: Ki= 4.6 nM; SLC6A2: Ki= 5.97 nM (human); Histamine H3 receptor: Ki>5 µM (human)
pK Values :
pKb: 10.02 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60835
MDL Number :
MFCD06801358
Beilstein Registry :
4297128
SMILES :
CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Duloxetine  Product Citations

See how others have used Duloxetine. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 24279796  Kinoshita, J. et al. 2013. Mol Pain. 9: 59.

PMID: # 23519740  Chae, JW. et al. 2013. Biomed. Chromatogr. 27: 953-5.

PMID: # 23920436  Nagayasu, K. et al. 2013. Int. J. Neuropsychopharmacol. 16: 2295-306.

Citations 1 to 3 of 3 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 66ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Handa et al Handa et al. (PubMed ID 26394856) found that duloxetine inhibited neuropathic pain in rats likely via down-regulation of TNF, NGF, and microglia. -SCBT Publication Review
Date published: 2015-05-08
  • y_2019, m_11, d_16, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_279011, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 31ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.