DroloxifeneA phenolic analog of tamoxifen

Droloxifene (CAS 82413-20-5)

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Application: A phenolic analog of tamoxifen
CAS Number: 82413-20-5
Molecular Weight: 387.51
Molecular Formula: C26H29NO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Droloxifene, an analog of tamoxifen, is an anti-estrogen triphenylthylene selective estrogen receptor modulator. Droloxifene inhibits bone resorption and turnover as well as estrogen-related bone loss in ovariectomized rats.Droloxifene acts as an estrogen receptor agonist in bone and as an estrogen receptor antagonist in breast tissue. In breast cancer cells, droloxifene decreases production of NO and increases levels of pro-apoptotic TGF-β. Droloxifene increases apoptosis in luteal cells in vivo, increasing levels of c-myc and increasing the Bax/Bcl-2 ratio.


References

1. Knabbe, C. et al. 1991. Am. J. Clin. Oncol. 14Suppl2 : S15-S20. PMID: 1835818

2. Leng, Y. et al. 2000. Eur. J. Pharmacol. 409(2): 123-131. PMID: 11104825

3. Leng, Y. et al. 2001. Acta Pharmacol. Sin. 22(2): 155-162. PMID: 11741521

4. Herrington, D.M. et al. 2001. J. Clin. Endocrinol. Metab. 86(9): 4216-4222. PMID: 11549652

5. Martin, J.H. et al. 2003. Oncol. Rep. 10(4): 979-984. PMID: 12792756

6. Qin, Z. et al. 2007. J. Med. Chem. 50(11): 2682-2692. PMID: 17489582

7. Shelly, W. et al. 2008. Obstet Gynecol Surv. 63(3): 163-181. PMID: 18279543

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
126-129° C
Boiling Point :
526.59° C at 760 mmHg (Predicted)
Density :
1.09 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
pK Values :
pKa: 9.82 (Predicted), pKb: 8.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3033767
MDL Number :
MFCD00865556
EC Number :
428-010-4
SMILES :
CCC(=C(C1=CC=C(C=C1)OCCN(C)C)C2=CC(=CC=C2)O)C3=CC=CC=C3

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Certificate of Analysis

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Droloxifene  Product Citations

See how others have used Droloxifene. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26303313  Mills, LJ. et al. 2015. Environ. Toxicol.

Citations 1 to 1 of 1 total
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