DPNA highly potent ERβ agonist

DPN (CAS 1428-67-7)

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Application: A highly potent ERβ agonist
CAS Number: 1428-67-7
Purity: >98%
Molecular Weight: 239.27
Molecular Formula: C15H13NO2
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DPN is a highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC50 values are 0.85 and 66 nM respectively). DPN relaxes mesenteric arteries in vitro.


1. Meyers, M.J., et al. 2001. J. Med. Chem. 44: 4230-4251. PMID: 11708925
2. Harrington, W.R., et al. 2003. Mol. Cell. Endocrinol. 206: 13-22. PMID: 12943986
3. Montgomery, S., et al. 2003. Br. J. Pharmacol. 139: 1249-1253. PMID: 12890703

Appearance :
Physical State :
Solubility :
Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25° C).
Storage :
Store at -20° C
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
ERβ: EC5050 = 0.85 nM; ERα: EC5050 = 66 nM
pK Values :
pKa: 9.41 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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DPN  Product Citations

See how others have used DPN. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28789972  Zhao, Y. et al. 2017. J. Steroid Biochem. Mol. Biol. 174: 96-113.

Citations 1 to 1 of 1 total
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