Doxycycline hyclate, also called doxycycline is an antimicrobial tetracycline that acts as an inhibitor of a wide range of matrix metalloproteinases (MMPs). This product has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Rheumatoid arthriitis studies indicate that doxycycline can block the degradation of type II collagen, and not type I collagen, as well as down regulate the expression levels and activity of MMP-8. Reports suggest that doxycycline blocks collagen activity and in smooth muscle studies increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration. Additionally, doxycycline has been observed to alter the expression of apicoplast genes in plasmodium falciparum, and inhibit tissue formation. Doxycycline hyclate is an inhibitor of MMP-1 and MMP-8.
1. Takafuji, E.T., et al. 1984. N. Engl. J. Med. 310: 497-500. PMID: 6363930
2. Suomalainen, K., et al. 1992. Antimicrob. Agents Chemother. 36: 227-229. PMID: 1317148
3. Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272: 31504-31509. PMID: 9395486
4. Dursun, D., et al. 2001. Am. J. Ophthalmol. 132: 8-13. PMID: 11438047
5. Lamparter, S., et al. 2002. J. Lab. Clin. Med. 139: 295-302. PMID: 12032490
6. Franco, C., et al. 2006. Am. J. Pathol. 168: 1697-1709. PMID: 16651635
7. Dahl, E.L., et al. 2006. Antimicrob. Agents Chemother. 50: 3124-3131. PMID: 16940111
See how others have used Doxycycline Hyclate. Click on the entry to view the PubMed entry .
PMID: # 29805991 2018. ACS Biomater Sci Eng. 4: 388-399.
PMID: # 28600321 Gilistro, E. et al. 2017. J. Cell. Sci. 130: 2564-2578.
PMID: # 27783893 Daer, R. et al. 2016. ACS Synth Biol.
PMID: # 25392493 Alfieri, JA. et al. 2014. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34: 15244-59.
PMID: # 12149459 Forloni, G. et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 10849-10854.
PMID: # 1317148 Suomalainen, K. et al. 1992. Antimicrob. Agents Chemother. 36: 227-229.
PMID: # 31388001 Nat Commun. 10: 3529.
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