Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity. It is known that this compound is the inactive form of 5-Fluorouridine (sc-221027), which is converted by enzymes in vivo . Studies indicate that 5-Fluorouridine causes apoptosis in HCT-116 colorectal carcinoma cells and along with cDNA microarray is a useful tool in studying the expression of 1,200 genes during apoptosis. It is believed that 5-Fluorouridine induces cytotoxicity in cells not only by inhibition of RNA synthesis and processing, but through other unknown mechanisms as well. Doxifluridine is an activator of NF κ B in macrophages.
1. Schmittgen, T.D., et al. 2005. Int. J. Oncol. 27: 297-306. PMID: 16010409
Soluble in water (50 mg/ml), DMSO (49 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and methanol.
Thymidylate kinase: Ki= 0.56 mM (Mycobacterium tuberculosis)
pKa: 7.4, pKb: 5.34
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Wang et alWang et al. (PubMed ID 22255032) found that the prodrug, Doxifluridine, was converted into 5-fluorouracil by endogenous thymidine phosphorylase and led to cell death in colorectal cancer cells. -SCBT Publication Review
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