Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity. It is known that this compound is the inactive form of 5-Fluorouridine (sc-221027), which is converted by enzymes in vivo . Studies indicate that 5-Fluorouridine causes apoptosis in HCT-116 colorectal carcinoma cells and along with cDNA microarray is a useful tool in studying the expression of 1,200 genes during apoptosis. It is believed that 5-Fluorouridine induces cytotoxicity in cells not only by inhibition of RNA synthesis and processing, but through other unknown mechanisms as well. Doxifluridine is an activator of NF κ B in macrophages.
1. Schmittgen, T.D., et al. 2005. Int. J. Oncol. 27: 297-306. PMID: 16010409
Soluble in water (50 mg/ml), DMSO (49 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and methanol.
Thymidylate kinase: Ki= 0.56 mM (Mycobacterium tuberculosis)
pKa: 7.4, pKb: 5.34
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 62ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Wang et alWang et al. (PubMed ID 22255032) found that the prodrug, Doxifluridine, was converted into 5-fluorouracil by endogenous thymidine phosphorylase and led to cell death in colorectal cancer cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.