Doxepin hydrochlorideA highly potent histamine H1 antagonist with affinity to H4 receptor

Doxepin hydrochloride (CAS 1229-29-4)

Doxepin hydrochloride | CAS 1229-29-4 is rated 5.0 out of 5 by 1.
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Application: A highly potent histamine H1 antagonist with affinity to H4 receptor
CAS Number: 1229-29-4
Purity: ≥98%
Molecular Weight: 315.84
Molecular Formula: C19H21NO•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Doxepin hydrochloride is a highly potent Histamine H1 Receptor (histamine H1) antagonist. Doxepin hydrochloride also binds to histamine H4 receptor. Doxepin hydrochloride is an inhibitor of AR and mAChR M.


References

1. Tran, V.T., et al. 1981. Eur. J. Pharmacol. 70: 501-509. PMID: 7238574
2. Luchins, D.J. 1983. Am J Psychiatry. 140: 1006-1009. PMID: 6346907
3. Nguyen, T., et al. 2001. Mol. Pharmacol. 59: 427-433. PMID: 11179435

Physical State :
Solid
Solubility :
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.
Storage :
Store at room temperature
Melting Point :
188-189° C
Boiling Point :
413.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HQ4375000
PubChem CID :
6419921
Merck Index :
14: 3435
MDL Number :
MFCD00079135
EC Number :
214-966-8
SMILES :
CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Park HJ; et al Park HJ; et al. (PubMed ID: 26253075) determined that Doxepin hydrochloride inhibited EAAT3 activity and glutamatergic neurotransmission. -SCBT Publication Review
Date published: 2015-06-26
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