Doxazosin Mesylate CAS: 77883-43-3
MF: C24H29N5O8S
MW: 547.59
An alpha-1-adrenoreceptor antagonist.

Doxazosin Mesylate (CAS 77883-43-3)

Doxazosin Mesylate | CAS 77883-43-3 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate
Application: Doxazosin Mesylate is an alpha-1-adrenoreceptor antagonist
CAS Number: 77883-43-3
Purity: ≥99%
Molecular Weight: 547.59
Molecular Formula: C24H29N5O8S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Doxazosin Mesylate is an α-blocker drug related to prazosin, specifically acting as an AR (α-1-adrenoceptor) antagonist. Doxazosin Mesylate inhibits the binding of norepinephrine to the α-1 receptors on the membrane of vascular smooth muscle cells. The primary effect of this inhibition is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.


References

1. McConnell, J.D., et al. 2003. N. Engl. J. Med. 349: 2387-2398. PMID: 14681504
2. Stafford, R.S., et al. 2004. JAMA. 291: 54-62. PMID: 14709576

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (slihgtly), DMSO (15 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), DMF, and methanol (slightly).
Storage :
Store at 4° C
Melting Point :
275-277° C
Boiling Point :
718° C at 760 mmHg (Predicted)
Density :
1.37 g/cm3
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 1.26 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
TK8044000
PubChem CID :
Merck Index :
14: 3433
MDL Number :
MFCD00216023
SMILES :
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Doxazosin Mesylate (CAS 77883-43-3)  Product Citations

See how others have used Doxazosin Mesylate (CAS 77883-43-3). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 14709576  Stafford, RS. et al. 2004. JAMA. 291: 54-62.

PMID: # 14681504  McConnell, JD. et al. 2003. N. Engl. J. Med. 349: 2387-2398.

PMID: # 33446713  Sci Rep. 1312.

Citations 1 to 3 of 3 total

What is the appearance of the chemical?

Asked by: two2igm05
Thank you for your question. The compound, sc-205656, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected] or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-19
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Rated 5 out of 5 by from Park et al Park et al. (PubMed ID 24952732) found that Doxazosin Mesylate inhibited angiogenesis in a xenograft human ovarian cancer model via Akt and mTOR phosphorylation inhibition and VEGFR-2 interaction. -SCBT Publication Review
Date published: 2015-02-23
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