Dotarizine (CAS 84625-59-2)
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Dotarizine is a broad spectrum Ca2+ antagonist and calcium channel protein inhibitor which blocks calcium uptake, [Ca2+]i rise and secretion via blockade of calcium channels. In addition, dotarizine selectively binds to vascular 5-HT receptors, blocking Ca2+ activated Cl -channels. Dotarizine is a piperazine derivative structurally related to flunarizine, which accounts for the similar function of the two compounds. Furthermore, flunarizine is a less selective antagonist than dotarizine towards SR (5-HT receptors). Alternate studies indicate that dotarizine can inhibit cell death in bovine adrenal medullary chromaffin cells by decreasing cytosolic Ba2+ concentration via Ca2+ channel blockade.
Dotarizine (CAS 84625-59-2) References
- Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. | Novalbos, J., et al. 1999. Eur J Pharmacol. 366: 309-17. PMID: 10082213
- Does nitric oxide participate in the mechanism of action of dotarizine? | Petkov, VD., et al. 1998. Acta Physiol Pharmacol Bulg. 23: 93-9. PMID: 10672335
- Ba(2+)-induced chromaffin cell death: cytoprotection by Ca(2+) channel antagonists. | Cano-Abad, MF., et al. 2000. Eur J Pharmacol. 402: 19-29. PMID: 10940353
- Mechanisms of blockade by the novel migraine prophylactic agent, dotarizine, of various brain and peripheral vessel contractility. | Ruiz-Nuño, A., et al. 2001. Eur J Pharmacol. 411: 289-99. PMID: 11164387
- Antimigraine dotarizine blocks P/Q Ca2+ channels and exocytosis in a voltage-dependent manner in chromaffin cells. | Ruiz-Nuño, A., et al. 2003. Eur J Pharmacol. 481: 41-50. PMID: 14637173
- Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells. | Gallego-Sandín, S., et al. 2005. Eur J Pharmacol. 520: 1-11. PMID: 16153637
- Effects of dotarizine on peripheral and pulmonary circulation and cardiac dynamics in dogs. | Cartheuser, CF., et al. 1994. Pharmacology. 48: 187-93. PMID: 8153146
- Effects of dotarizine on 45Ca2+ movements and contractile responses in vascular smooth muscle. | Tejerina, T., et al. 1993. Eur J Pharmacol. 239: 75-81. PMID: 8223916
- Effect of dotarizine on K(+)-stimulated [3H]-serotonin and [3H]-acetylcholine release from rat hippocampus. | Hadjiivanova, C., et al. 1997. Gen Pharmacol. 28: 129-32. PMID: 9112089
- Serotonergic effects of dotarizine in coronary artery and in oocytes expressing 5-HT2 receptors. | Montiel, C., et al. 1997. Eur J Pharmacol. 332: 183-93. PMID: 9286620
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dotarizine, 5 mg | sc-203033 | 5 mg | $84.00 | |||
Dotarizine, 25 mg | sc-203033A | 25 mg | $244.00 |