DonepezilShown to increase levels of cortical acetylcholine

Donepezil (CAS 120014-06-4)

Donepezil | CAS 120014-06-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_21, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_279006, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 101ms
  • REVIEWS, PRODUCT
Synonym: Aricept
Application: Shown to increase levels of cortical acetylcholine
CAS Number: 120014-06-4
Purity: ≥99%
Molecular Weight: 379.50
Molecular Formula: C24H29NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Donepezil is a noncompetitive acetylcholineesterase inhibitor, which can readily cross the blood brain barrier and increase the concentration of cortical acetylcholine. It is known that Donepezil is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil selectively inhibits acetylcholineesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats.


References

1. Shintani, E.Y., et al. 1997. Am J Health Syst Pharm. 54: 2805-2810. PMID: 9428950
2. Bryson, H.M. and Benfield, P. 1997. Drugs Aging. 10: 234-240. PMID: 9108896

Physical State :
Solid
Solubility :
Soluble in chloroform (~50 mg/ml), and acetone (~25 mg/ml).
Storage :
Store at -20° C
Melting Point :
206.72 °C (Predicted)
Boiling Point :
~527.9 °C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Acetylcholinesterase: IC50 = 1.7 nM (rat); AChE: IC50 = 2 nM (human); Acetylcholinesterase: IC50 = 4.2 nM (bovine); Choline acetylase: IC50 = 5.3 nM (rat); Acetylcholinesterase: IC50 = 5.7 nM (mouse)
Ki Data :
Acetylcholinesterase: Ki= 2.9 nM (bovine); AChE: Ki= 7.2 nM (human); Sigma Receptor: Ki= 14.6 nM (human); Acetylcholinesterase: Ki= 56 nM (electric eel); Butyrylcholinesterase: Ki= 640 nM (horse)
pK Values :
pKb: 8.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3152
Merck Index :
14: 3419
MDL Number :
MFCD00912833
EC Number :
601-651-9
Beilstein Registry :
7081955
SMILES :
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Donepezil  Product Citations

See how others have used Donepezil. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25498859  Chae, YJ. et al. 2015. Brain Res. 1597: 77-85.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 10ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Bryson et al Bryson et al. (PubMed ID 9108896) found that Donepezil inhibited acetylcholinerase activity in human red blood cells and increased acetylcholine in the cerebral cortex and hippocampus of rats. It was also used to improve cognitive function in patients with Alzheimer s disease. -SCBT Publication Review
Date published: 2015-03-31
  • y_2019, m_9, d_21, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_279006, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.